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Creatinine ClearanceCalculator · the Gault Standard

Our Medical Reviewers

Clinical pages on this site are reviewed by a credentialed nephrologist before they are marked production-ready, under the Gault Standard. The reviewer verifies formulas, normal ranges, CKD cutoffs, and renal drug-dosing thresholds against authoritative sources.

Medical Reviewer

Dr. Rishi Kumar Kafle, MBBS, MD, FASN

Consultant Nephrologist · Nepal Mediciti, Kathmandu

Dr. Rishi Kumar Kafle is a senior consultant nephrologist and a Fellow of the American Society of Nephrology (FASN). He is widely recognised for establishing dialysis services in Nepal and founding the National Kidney Center, with decades of clinical experience in kidney disease and renal care. He reviews the clinical content on this site — the kidney-function equations, normal ranges, CKD staging, and renal drug-dosing guidance — for accuracy and safe interpretation.

Verify credentials at Nepal Mediciti →

The Review Process

Every clinical page moves through the same sequence before it is considered production-ready, and the same sequence again at each refresh:

  • The author drafts the page from primary sources and the calculator engine.
  • Every clinical claim is fact-checked and carries a citation (see our references).
  • A credentialed clinician reviews the page and signs off on its clinical values.
  • The page records a “last reviewed” date and is re-checked every 3–6 months.

The clinician's role is specifically to confirm clinical correctness — that a formula is applied to the right population, that a normal range matches current guidance, and that a renal drug-dosing threshold reflects the FDA label. Citation and automated testing handle accuracy of fact and arithmetic; the reviewer handles clinical judgment, which neither can replace.

Review Status

Dr. Kafle's name and credentials appear in the reviewer byline and in each page's structured data (reviewedBy). He has reviewed the calculator engine outputs and the renal drug-dosing thresholds in our registry, which are now marked reviewer-verified. Clinical pages enter a regular refresh cycle and are re-reviewed every 3–6 months, or sooner when guidance changes. Even with that sign-off, every page asks you to confirm dosing against the current drug label and your own clinical judgment — verification raises trust, it does not replace bedside decision-making.

What the Reviewer Verifies

The reviewer's sign-off covers the clinical substance of a page: that each equation is applied to the right population, that normal ranges and CKD cutoffs match current KDIGO and National Kidney Foundation guidance, and that renal drug-dosing thresholds reflect the FDA label. Until a value carries that sign-off it remains reviewer-pending, regardless of how well it is cited — a well-sourced fact still needs clinical judgment behind it before this site presents it as authoritative.

Dr. Henry Gault — Historical Namesake

Dr. Henry Gault (1925–2003) was a Canadian nephrologist who, with his trainee Donald W. Cockcroft, derived the equation that bears their names. Their paper, “Prediction of creatinine clearance from serum creatinine,” appeared in the journal Nephron in 1976. It showed that creatinine clearance could be estimated from a single blood test plus a patient's age, sex, and weight — without the cumbersome 24-hour urine collection that had been standard.

That simplicity is why the equation endured. The Cockcroft–Gault formula became one of the most cited in clinical medicine and remains the basis on which most renal drug-dosing thresholds and FDA labels are written — the reason it is still preferred over newer equations for adjusting medication doses. We call our methodology the Gault Standard in recognition of that lineage: every calculator on this site follows the validated Cockcroft–Gault approach and cites its primary sources.

Honouring Dr. Gault as the historical author of the method is different from claiming he reviewed this site. The distinction matters on a medical site: a credentialed, living clinician must still sign off on the clinical values before any page is presented as authoritative. Read more about the equation he co-created in the Cockcroft–Gault equation explained.